› 8bx5

Electron Microscopy
4.2Å resolution

Alvinella pompejana nicotinic acetylcholine receptor Alpo4 in apo state (dataset 1)

Released:
DOI: 10.2210/pdb8bx5/pdb
PDB entry 8bx5 coloured by chain, front view.
PDB entry 8bx5 coloured by chain, side view.
PDB entry 8bx5 coloured by chain, top view.
Source organism: Alvinella pompejana
Primary publication:
Sterol derivative binding to the orthosteric site causes conformational changes in an invertebrate Cys-loop receptor.
De Gieter S, Gallagher C, Wijckmans E, Pasini D, Ulens C, Efremov RG
OpenAccess logo Elife 12 (2023)
PMID: 37395731
Related structures: EMD-16308

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo pentamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-220751 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Acetylcholine receptor Chains: A, B, C, D, E
Molecule details ›
Chains: A, B, C, D, E
Length: 475 amino acids
Theoretical weight: 54.15 KDa
Source organism: Alvinella pompejana
Expression system: Spodoptera frugiperda

Ligands and Environments

1 bound ligand:
Ligand NAG 4 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.2Å
Relevant EMDB volumes: EMD-16308
Expression system: Spodoptera frugiperda

Quick links

Citations

1 mention without citation

Sterol derivative binding to the orthosteric site causes conformational changes in an invertebrate Cys-loop receptor.
De Gieter et al. (2023)