› 8c1c

Electron Microscopy
4.1Å resolution

Structure of IgE bound to the ectodomain of FceRIa

Released:
DOI: 10.2210/pdb8c1c/pdb
PDB entry 8c1c coloured by chain, front view.
PDB entry 8c1c coloured by chain, side view.
PDB entry 8c1c coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Andersen GR, Jensen RK
Related structures: EMD-16378

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134643 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (6 distinct):
Immunoglobulin heavy constant epsilon Chains: H, X
Molecule details ›
Chains: H, X
Length: 426 amino acids
Theoretical weight: 46.83 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P01854 (Residues: 1-423; Coverage: 78%)
Gene name: IGHE
Sequence domains: Immunoglobulin C1-set domain
Immunoglobulin kappa constant Chains: L, Y
Molecule details ›
Chains: L, Y
Length: 107 amino acids
Theoretical weight: 11.76 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P01834 (Residues: 1-107; Coverage: 100%)
Gene name: IGKC
Sequence domains: Immunoglobulin C1-set domain
High affinity immunoglobulin epsilon receptor subunit alpha Chain: R
Molecule details ›
Chain: R
Length: 171 amino acids
Theoretical weight: 19.88 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P12319 (Residues: 29-199; Coverage: 74%)
Gene names: FCE1A, FCER1A
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, MAN
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
1 bound ligand:
Ligand NAG 2 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.1Å
Relevant EMDB volumes: EMD-16378
Expression system: Homo sapiens

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