› 8c1d

X-ray diffraction
2.12Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127232 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Aurora kinase A Chain: A
Molecule details ›
Chain: A
Length: 265 amino acids
Theoretical weight: 30.75 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O14965 (Residues: 126-388; Coverage: 65%)
Gene names: AIK, AIRK1, ARK1, AURA, AURKA, AYK1, BTAK, IAK1, STK15, STK6
Sequence domains: Protein kinase domain

Ligands and Environments

7 bound ligands:
Ligand T2F 1 x T2F
Ligand ADP 1 x ADP
Ligand MG 2 x MG
Ligand T5L 1 x T5L
Ligand SO4 6 x SO4
Ligand DMS 2 x DMS
Ligand ACT 1 x ACT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE MASSIF-3
Spacegroup: P6122
Unit cell:
a: 81.341Å b: 81.341Å c: 171.531Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.212 0.21 0.238
Expression system: Escherichia coli BL21(DE3)

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