› 8c1l

X-ray diffraction
2Å resolution

Crystal structure of HNF4 alpha LBD in complexes with palmitic acid and GRIP-1 peptide

Released:
DOI: 10.2210/pdb8c1l/pdb
PDB entry 8c1l coloured by chain, front view.
PDB entry 8c1l coloured by chain, side view.
PDB entry 8c1l coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Ni X, Merk D, Zhubi R, Knapp S, Structural Genomics Consortium (SGC)

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-273720 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Hepatocyte nuclear factor 4-alpha Chains: A, B
Molecule details ›
Chains: A, B
Length: 232 amino acids
Theoretical weight: 26.21 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P41235 (Residues: 148-377; Coverage: 49%)
Gene names: HNF4, HNF4A, NR2A1, TCF14
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Nuclear receptor coactivator 2 Chains: D, E
Molecule details ›
Chains: D, E
Length: 9 amino acids
Theoretical weight: 1.16 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q15596 (Residues: 687-695; Coverage: 1%)
Gene names: BHLHE75, NCOA2, SRC2, TIF2

Ligands and Environments

2 bound ligands:
Ligand PLM 2 x PLM
Ligand EDO 3 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P21
Unit cell:
a: 57.277Å b: 82.457Å c: 57.36Å
α: 90° β: 111.84° γ: 90°
R-values:
R R work R free
0.197 0.195 0.237
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided

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