› 8c1w

Electron Microscopy
3.9Å resolution

Tetrameric 5-HT3A receptor in Salipro (apo, asymmetric)

Released:
DOI: 10.2210/pdb8c1w/pdb
PDB entry 8c1w coloured by chain, front view.
PDB entry 8c1w coloured by chain, side view.
PDB entry 8c1w coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structure of tetrameric forms of the serotonin-gated 5-HT3A receptor ion channel.
Introini B, Cui W, Chu X, Zhang Y, Alves AC, Eckhardt-Strelau L, Golusik S, Tol M, Vogel H, Yuan S, Kudryashev M
EMBO J 43 4451-4471 (2024)
PMID: 39232129
Related structures: EMD-16384

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-273417 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
5-hydroxytryptamine receptor 3A Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 538 amino acids
Theoretical weight: 60.67 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: P23979 (Residues: 33-303, 305-489; Coverage: 98%)
Gene names: 5ht3, Htr3, Htr3a
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.9Å
Relevant EMDB volumes: EMD-16384
Expression system: Homo sapiens

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