› 8c2z

X-ray diffraction
1.91Å resolution

Crystal structure of DYRK1B in complex with AZ191

Released:
DOI: 10.2210/pdb8c2z/pdb
PDB entry 8c2z coloured by chain, front view.
PDB entry 8c2z coloured by chain, side view.
PDB entry 8c2z coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Grygier P, Pustelny K, Dubin G, Czarna A

Function and Biology Details

Reaction catalysed: 
ATP + L-seryl/L-threonyl/L-tyrosyl-[protein] = ADP + O-phospho-L-seryl/O-phospho-L-threonyl/O-phospho-L-tyrosyl-[protein]
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-238999 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Dual specificity tyrosine-phosphorylation-regulated kinase 1B Chain: A
Molecule details ›
Chain: A
Length: 372 amino acids
Theoretical weight: 42.9 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9Y463 (Residues: 77-442; Coverage: 58%)
Gene names: DYRK1B, MIRK
Sequence domains: Protein kinase domain

Ligands and Environments

2 bound ligands:
Ligand QS0 1 x QS0
Ligand MN 3 x MN
1 modified residue:
Ligand PTR 1 x PTR

Experiments and Validation Details

Entry percentile scores
X-ray source: PETRA III, DESY BEAMLINE P11
Spacegroup: C2221
Unit cell:
a: 115.896Å b: 121.509Å c: 54.021Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.179 0.177 0.22
Expression system: Escherichia coli

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