8c3r

X-ray diffraction
2.06Å resolution

Crystal structure of DYRK1A in complex with gossypin

Released:
Model geometry
Fit model/data
Source organism: Homo sapiens
Entry authors: Grygier P, Pustelny K, Dubin G, Czarna A

Function and Biology Details

Reactions catalysed:
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate
ATP + L-seryl/L-threonyl/L-tyrosyl-[protein] = ADP + O-phospho-L-seryl/O-phospho-L-threonyl/O-phospho-L-tyrosyl-[protein]
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
PDBe Complex ID:
PDB-CPX-171789 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Dual specificity tyrosine-phosphorylation-regulated kinase 1A Chains: A, B
Molecule details ›
Chains: A, B
Length: 370 amino acids
Theoretical weight: 43.18 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q13627 (Residues: 126-489; Coverage: 48%)
Gene names: DYRK, DYRK1A, MNB, MNBH
Sequence domains: Protein kinase domain

Ligands and Environments

2 bound ligands:
1 modified residue:

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: BESSY BEAMLINE 14.2
Spacegroup: P63
Unit cell:
a: 132.126Å b: 132.126Å c: 90.485Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.187 0.186 0.209
Expression system: Escherichia coli