› 8c62

X-ray diffraction
2.31Å resolution

Crystal structure of cisplatin/B-DNA adduct

Released:
DOI: 10.2210/pdb8c62/pdb
PDB entry 8c62 coloured by chain, front view.
PDB entry 8c62 coloured by chain, side view.
PDB entry 8c62 coloured by chain, top view.
Source organism: synthetic construct
Primary publication:
On the mechanism of action of arsenoplatins: arsenoplatin-1 binding to a B-DNA dodecamer.
Troisi R, Tito G, Ferraro G, Sica F, Massai L, Geri A, Cirri D, Messori L, Merlino A
Dalton Trans (2024)
PMID: 38270175

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-239329 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
DNA (5'-D(*CP*GP*CP*GP*AP*AP*TP*TP*CP*GP*CP*G)-3') Chains: A, B
Molecule details ›
Chains: A, B
Length: 12 nucleotides
Theoretical weight: 3.66 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand PT 4 x PT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-2
Spacegroup: P212121
Unit cell:
a: 24.725Å b: 41.001Å c: 66.483Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.235 0.231 0.266
Expression system: Not provided

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