› 8c7a

Solution NMR

Slow cation movements within tetramolecular G-quadruplex: vacant cation binding sites in addition to all syn G-quartet

Released:
DOI: 10.2210/pdb8c7a/pdb
PDB entry 8c7a coloured by chain, ensemble of 10 models, front view.
PDB entry 8c7a coloured by chain, ensemble of 10 models, side view.
PDB entry 8c7a coloured by chain, ensemble of 10 models, top view.
Source organism: Homo sapiens
Primary publication:
Insight into Tetramolecular DNA G-Quadruplexes Associated with ALS and FTLD: Cation Interactions and Formation of Higher-Ordered Structure.
Zalar M, Wang B, Plavec J, Šket P
OpenAccess logo Int J Mol Sci 24 (2023)
PMID: 37686239

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-235632 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
DNA (5'-D(*GP*GP*GP*GP*CP*C)-3') Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 6 nucleotides
Theoretical weight: 1.85 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 9%
Refinement method: simulated annealing
Expression system: Not provided

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