› 8ca0

Solution NMR

Macrophage inhibitory factor (MIF) in complex with small molecule PAV174

Released:
DOI: 10.2210/pdb8ca0/pdb
PDB entry 8ca0 coloured by chain, ensemble of 4 models, front view.
PDB entry 8ca0 coloured by chain, ensemble of 4 models, side view.
PDB entry 8ca0 coloured by chain, ensemble of 4 models, top view.
Source organism: Homo sapiens
Entry authors: Mueller A, Torres F, Roland R, Korth C

Function and Biology Details

Reactions catalysed: 
Keto-phenylpyruvate = enol-phenylpyruvate
L-dopachrome = 5,6-dihydroxyindole-2-carboxylate
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146863 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Macrophage migration inhibitory factor Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 114 amino acids
Theoretical weight: 12.36 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P14174 (Residues: 2-115; Coverage: 99%)
Gene names: GLIF, MIF, MMIF
Sequence domains: Macrophage migration inhibitory factor (MIF)

Ligands and Environments

1 bound ligand:
Ligand VIU 1 x VIU
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 1%
Refinement method: simulated annealing
Expression system: Escherichia coli

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