› 8caq

Electron Microscopy
2.3Å resolution

Structure of Tau filaments Type I from Subacute Sclerosing Panencephalitis

Released:
DOI: 10.2210/pdb8caq/pdb
PDB entry 8caq coloured by chain, front view.
PDB entry 8caq coloured by chain, side view.
PDB entry 8caq coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Identical tau filaments in subacute sclerosing panencephalitis and chronic traumatic encephalopathy.
Qi C, Hasegawa M, Takao M, Sakai M, Sasaki M, Mizutani M, Akagi A, Iwasaki Y, Miyahara H, Yoshida M, Scheres SHW, Goedert M
OpenAccess logo Acta Neuropathol Commun 11 74 (2023)
PMID: 37143123
Related structures: EMD-16532

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo pentamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145402 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Microtubule-associated protein tau Chains: A, B, C, D, E
Molecule details ›
Chains: A, B, C, D, E
Length: 441 amino acids
Theoretical weight: 45.92 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P10636 (Residues: 1-758; Coverage: 58%)
  • Best match: P10636-8 (Residues: 1-441)
Gene names: MAPT, MAPTL, MTBT1, TAU
Sequence domains: Tau and MAP protein, tubulin-binding repeat

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.3Å
Relevant EMDB volumes: EMD-16532

Quick links

Citations

1 review citation

Molecular pathology of neurodegenerative diseases by cryo-EM of amyloids.
Scheres et al. (2023)
2 other articles