› 8cgg

Electron Microscopy
2.5Å resolution

Structure of TDP-43 amyloid filament from type A FTLD-TDP (variant 2)

Released:
DOI: 10.2210/pdb8cgg/pdb
PDB entry 8cgg coloured by chain, front view.
PDB entry 8cgg coloured by chain, side view.
PDB entry 8cgg coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
TDP-43 forms amyloid filaments with a distinct fold in type A FTLD-TDP.
Arseni D, Chen R, Murzin AG, Peak-Chew SY, Garringer HJ, Newell KL, Kametani F, Robinson AC, Vidal R, Ghetti B, Hasegawa M, Ryskeldi-Falcon B
Nature (2023)
PMID: 37532939
Related structures: EMD-16642

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo pentamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171567 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
TAR DNA-binding protein 43 Chains: A, B, C, D, U
Molecule details ›
Chains: A, B, C, D, U
Length: 414 amino acids
Theoretical weight: 44.78 KDa
Source organism: Homo sapiens
Expression system: Homo
UniProt:
  • Canonical: Q13148 (Residues: 1-414; Coverage: 100%)
Gene names: TARDBP, TDP43
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.5Å
Relevant EMDB volumes: EMD-16642
Expression system: Homo

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Citations

1 review citation

Molecular pathology of neurodegenerative diseases by cryo-EM of amyloids.
Scheres et al. (2023)
6 other articles