EC 3.1.26.13: Retroviral ribonuclease H
Reaction catalysed:
Endohydrolysis of RNA in RNA/DNA hybrids. Three different cleavage modes: 1. sequence-specific internal cleavage of RNA. Human immunodeficiency virus type 1 and Moloney murine leukemia virus enzymes prefer to cleave the RNA strand one nucleotide away from the RNA-DNA junction. 2. RNA 5'-end directed cleavage 13-19 nucleotides from the RNA end. 3. DNA 3'-end directed cleavage 15-20 nucleotides away from the primer terminus.
Systematic name:
-
Alternative Name(s):
- HIV RNase H
- RT/RNase H
- Retroviral reverse transcriptase RNaseH
GO terms
Biochemical function:
Biological process:
Cellular component:
- not assigned
Protein family (Pfam)
InterPro annotations