› 8cl0

Electron Microscopy
3.12Å resolution

HIV-1 mature capsid hexamer next to pentamer (type I) from CA-IP6 CLPs bound to Nup153 peptide.

Released:
DOI: 10.2210/pdb8cl0/pdb
PDB entry 8cl0 coloured by chain, front view.
PDB entry 8cl0 coloured by chain, side view.
PDB entry 8cl0 coloured by chain, top view.
Source organisms:
Primary publication:
Two structural switches in HIV-1 capsid regulate capsid curvature and host factor binding.
Stacey JCV, Tan A, Lu JM, James LC, Dick RA, Briggs JAG
OpenAccess logo Proc Natl Acad Sci U S A 120 e2220557120 (2023)
PMID: 37040417
Related structures: EMD-16708

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dodecamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146192 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Capsid protein p24 Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 232 amino acids
Theoretical weight: 25.76 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P12493 (Residues: 132-363; Coverage: 46%)
Gene name: gag
Sequence domains:
Nuclear pore complex protein Nup153 Chains: G, H, I, J, K, L
Molecule details ›
Chains: G, H, I, J, K, L
Length: 17 amino acids
Theoretical weight: 1.69 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P49790 (Residues: 1407-1423; Coverage: 1%)
Gene name: NUP153

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.12Å
Relevant EMDB volumes: EMD-16708
Expression systems:
  • Escherichia coli BL21
  • Not provided

Quick links

Citations

2 review citations

HIV Infection: Shaping the Complex, Dynamic, and Interconnected Network of the Cytoskeleton.
Cabrera-Rodríguez et al. (2023)
1 more