› 8clk

Electron Microscopy
3.5Å resolution

TFIIIC TauA complex

Released:
DOI: 10.2210/pdb8clk/pdb
PDB entry 8clk coloured by chain, front view.
PDB entry 8clk coloured by chain, side view.
PDB entry 8clk coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural insights into human TFIIIC promoter recognition.
Seifert-Davila W, Girbig M, Hauptmann L, Hoffmann T, Eustermann S, Müller CW
Sci Adv 9 eadh2019 (2023)
PMID: 37418517
Related structures: EMD-16715

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
PDBe Complex ID:
PDB-CPX-218752 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
General transcription factor 3C polypeptide 1 Chain: A
Molecule details ›
Chain: A
Length: 2158 amino acids
Theoretical weight: 244.2 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q12789 (Residues: 1-2109; Coverage: 100%)
Gene name: GTF3C1
Sequence domains: B-block binding subunit of TFIIIC
General transcription factor 3C polypeptide 3 Chain: D
Molecule details ›
Chain: D
Length: 886 amino acids
Theoretical weight: 101.39 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9Y5Q9 (Residues: 1-886; Coverage: 100%)
Gene name: GTF3C3
Sequence domains: Tetratricopeptide repeat
General transcription factor 3C polypeptide 5 Chain: E
Molecule details ›
Chain: E
Length: 533 amino acids
Theoretical weight: 61.47 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9Y5Q8 (Residues: 1-519; Coverage: 100%)
Gene names: CDABP0017, GTF3C5
Sequence domains:
General transcription factor 3C polypeptide 6 Chain: F
Molecule details ›
Chain: F
Length: 213 amino acids
Theoretical weight: 24.07 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q969F1 (Residues: 1-213; Coverage: 100%)
Gene names: C6orf51, CDA020, GTF3C6, NPD020
Sequence domains: TFIIIC subunit triple barrel domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.5Å
Relevant EMDB volumes: EMD-16715
Expression system: Spodoptera frugiperda

Quick links

Citations

2 citation in other articles

The Conserved Chromatin Remodeler SMARCAD1 Interacts with TFIIIC and Architectural Proteins in Human and Mouse.
Sachs et al. (2023)
1 more