› 8ct6

Electron Microscopy
3.1Å resolution

1F8 mAb in complex with the computationally optimized broadly reactive H1 influenza hemagglutinin P1

Released:
DOI: 10.2210/pdb8ct6/pdb
PDB entry 8ct6 coloured by chain, front view.
PDB entry 8ct6 coloured by chain, side view.
PDB entry 8ct6 coloured by chain, top view.
Source organisms:
Primary publication:
Structural insights into the broad protection against H1 influenza viruses by a computationally optimized hemagglutinin vaccine.
Dzimianski JV, Han J, Sautto GA, O'Rourke SM, Cruz JM, Pierce SR, Ecker JW, Carlock MA, Nagashima KA, Mousa JJ, Ross TM, Ward AB, DuBois RM
OpenAccess logo Commun Biol 6 454 (2023)
PMID: 37185989
Related structures: EMD-26983

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero heptamer (preferred)
PDBe Complex ID:
PDB-CPX-226012 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (6 distinct):
COBRA P1 HA Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 562 amino acids
Theoretical weight: 63.26 KDa
Source organism: Influenza A virus
Expression system: Homo sapiens
1F8 light chain Chains: K, L
Molecule details ›
Chains: K, L
Length: 218 amino acids
Theoretical weight: 23.92 KDa
Source organism: Mus musculus
Expression system: Cricetulus griseus
1F8 heavy chain Chains: H, J
Molecule details ›
Chains: H, J
Length: 222 amino acids
Theoretical weight: 23.9 KDa
Source organism: Mus musculus
Expression system: Cricetulus griseus

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer
1 bound ligand:
Ligand NAG 10 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.1Å
Relevant EMDB volumes: EMD-26983
Expression systems:
  • Homo sapiens
  • Cricetulus griseus

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