› 8ctd

Electron Microscopy
3.42Å resolution

Human excitatory amino acid transporter 3 (EAAT3) protomer with bound glutamate in an outward facing state

Released:
DOI: 10.2210/pdb8ctd/pdb
PDB entry 8ctd coloured by chain, front view.
PDB entry 8ctd coloured by chain, side view.
PDB entry 8ctd coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Symport and antiport mechanisms of human glutamate transporters.
Qiu B, Boudker O
OpenAccess logo Nat Commun 14 2579 (2023)
PMID: 37142617
Related structures: EMD-26986

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-154931 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Excitatory amino acid transporter 3 Chain: A
Molecule details ›
Chain: A
Length: 526 amino acids
Theoretical weight: 57.12 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P43005 (Residues: 1-524; Coverage: 100%)
Gene names: EAAC1, EAAT3, HEAAC1, SLC1A1
Sequence domains: Sodium:dicarboxylate symporter family

Ligands and Environments

3 bound ligands:
Ligand GLU 1 x GLU
Ligand NA 3 x NA
Ligand HG 1 x HG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.42Å
Relevant EMDB volumes: EMD-26986
Expression system: Homo sapiens

Quick links

Citations

1 review citation

Ion and lipid orchestration of secondary active transport.
Drew et al. (2024)
1 other article