8ctg

Electron Microscopy
3.8Å resolution

Extracellular architecture of an engineered canonical Wnt signaling ternary complex

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-131061 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Frizzled-8 Chain: A
Molecule details ›
Chain: A
Length: 132 amino acids
Theoretical weight: 15.06 KDa
Source organism: Mus musculus
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: Q61091 (Residues: 28-150; Coverage: 19%)
Gene name: Fzd8
Sequence domains: Fz domain
Protein Wnt-8 Chain: B
Molecule details ›
Chain: B
Length: 327 amino acids
Theoretical weight: 36.68 KDa
Source organism: Xenopus laevis
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: P28026 (Residues: 22-329; Coverage: 91%)
Gene name: wnt8
Sequence domains: wnt family
Low-density lipoprotein receptor-related protein 6 Chain: C
Molecule details ›
Chain: C
Length: 649 amino acids
Theoretical weight: 73.38 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: O75581 (Residues: 20-629; Coverage: 38%)
Gene name: LRP6
Sequence domains:

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.8Å
Relevant EMDB volumes: EMD-26989
Expression system: Drosophila melanogaster