Function and Biology Details
Reaction catalysed:
S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- WD40 repeat
- tRNA (guanine-N-7) methyltransferase, Trmb type
- tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit
- S-adenosyl-L-methionine-dependent methyltransferase superfamily
- WD40/YVTN repeat-like-containing domain superfamily
- WD40-repeat-containing domain superfamily
- tRNA (guanine-N-7) methyltransferase catalytic subunit Trm8, eukaryote
- tRNA
Structure analysis Details
Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-250281 (preferred)
Entry contents:
2 distinct polypeptide molecules
1 distinct RNA molecule
1 distinct RNA molecule
Macromolecules (3 distinct):
tRNA (guanine-N(7)-)-methyltransferase
Molecule details ›
Chain: A
Length: 276 amino acids
Theoretical weight: 31.52 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
Sequence domains: Putative methyltransferase
Length: 276 amino acids
Theoretical weight: 31.52 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical:
Q9UBP6 (Residues: 1-276; Coverage: 100%)
Sequence domains: Putative methyltransferase
tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4
Molecule details ›
Chain: B
Length: 428 amino acids
Theoretical weight: 47.36 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
Sequence domains: WD domain, G-beta repeat
Length: 428 amino acids
Theoretical weight: 47.36 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical: P57081 (Residues: 1-412; Coverage: 100%)
Sequence domains: WD domain, G-beta repeat
