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CamA Adenine Methyltransferase Complexed to Cognate Substrate DNA and Inhibitor MTA

Source organism: Clostridioides difficile
Biochemical function: site-specific DNA-methyltransferase (adenine-specific) activity
Biological process: methylation
Cellular component: not assigned

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EC 2.1.1.72: Site-specific DNA-methyltransferase (adenine-specific)

Reaction catalysed:
S-adenosyl-L-methionine + adenine in DNA = S-adenosyl-L-homocysteine + N-6-methyladenine in DNA
Systematic name:
S-adenosyl-L-methionine:adenine in DNA N(6)-methyltransferase
Alternative Name(s):
  • Modification methylase
  • N-6 adenine-specific DNA methylase
  • Restriction-modification system

GO terms

Sequence families

Pfam Protein families (Pfam)
PF12950
Domain description: TaqI-like C-terminal specificity domain
Occurring in:
  1. site-specific DNA-methyltransferase (adenine-specific)
The deposited structure of PDB entry 8cxs contains 3 copies of Pfam domain PF12950 (TaqI-like C-terminal specificity domain) in site-specific DNA-methyltransferase (adenine-specific). Showing 1 copy in chain B.

PF07669
Domain description: Eco57I restriction-modification methylase
Occurring in:
  1. site-specific DNA-methyltransferase (adenine-specific)

InterPro InterPro annotations
IPR029063
Domain description: S-adenosyl-L-methionine-dependent methyltransferase superfamily
Occurring in:
  1. site-specific DNA-methyltransferase (adenine-specific)
IPR025931
Domain description: TaqI-like C-terminal specificity domain
Occurring in:
  1. site-specific DNA-methyltransferase (adenine-specific)
IPR002052
Domain description: DNA methylase, N-6 adenine-specific, conserved site
Occurring in:
  1. site-specific DNA-methyltransferase (adenine-specific)
IPR003356
Domain description: DNA methylase, adenine-specific
Occurring in:
  1. site-specific DNA-methyltransferase (adenine-specific)

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