› 8cz1

Electron Microscopy
3Å resolution

CryoEM structure of amplified alpha-synuclein fibril class B type II with extended core from DLB case VII

Released:
DOI: 10.2210/pdb8cz1/pdb
PDB entry 8cz1 coloured by chain, front view.
PDB entry 8cz1 coloured by chain, side view.
PDB entry 8cz1 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Zhou Y, Sokratian A, Xu E, Viverette E, Dillard L, Yuan Y, Li JY, Matarangas A, Bouvette J, Borgnia M, Bartesaghi A, West A
Related structures: EMD-27090

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dodecamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-153504 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Alpha-synuclein Chains: A, B, C, D, E, F, I, J, K, L, M, N
Molecule details ›
Chains: A, B, C, D, E, F, I, J, K, L, M, N
Length: 140 amino acids
Theoretical weight: 14.48 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'
UniProt:
  • Canonical: P37840 (Residues: 1-140; Coverage: 100%)
Gene names: NACP, PARK1, SNCA
Sequence domains: Synuclein

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3Å
Relevant EMDB volumes: EMD-27090
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'

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