› 8cz9

X-ray diffraction
1.65Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-271512 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
SH2B adapter protein 3 Chain: A
Molecule details ›
Chain: A
Length: 110 amino acids
Theoretical weight: 12.58 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: O09039 (Residues: 328-437; Coverage: 20%)
Gene names: Lnk, Sh2b3
Sequence domains: SH2 domain
Tyrosine-protein kinase JAK2 Chain: C
Molecule details ›
Chain: C
Length: 8 amino acids
Theoretical weight: 1.06 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: O60674 (Residues: 811-818; Coverage: 1%)
Gene name: JAK2

Ligands and Environments

1 bound ligand:
Ligand CL 1 x CL
1 modified residue:
Ligand PTR 1 x PTR

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: C2
Unit cell:
a: 75.829Å b: 37.618Å c: 50.497Å
α: 90° β: 108.76° γ: 90°
R-values:
R R work R free
0.188 0.185 0.216
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

1 review citation

Monogenic lupus: insights into disease pathogenesis and therapeutic opportunities.
Qin et al. (2024)

1 mention without citation

Rare SH2B3 coding variants in lupus patients impair B cell tolerance and predispose to autoimmunity.
Zhang et al. (2024)