› 8czh

X-ray diffraction
1.3Å resolution

Human BAK in complex with the dM2 peptide

Released:
DOI: 10.2210/pdb8czh/pdb
Model geometry
Fit model/data
PDB entry 8czh coloured by chain, front view.
PDB entry 8czh coloured by chain, side view.
PDB entry 8czh coloured by chain, top view.
Source organisms:
Primary publication:
Peptides from human BNIP5 and PXT1 and non-native binders of pro-apoptotic BAK can directly activate or inhibit BAK-mediated membrane permeabilization.
Aguilar F, Yu S, Grant RA, Swanson S, Ghose D, Su BG, Sarosiek KA, Keating AE
Structure (2023)
PMID: 36706751

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-277799 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Bcl-2 homologous antagonist/killer Chain: A
Molecule details ›
Chain: A
Length: 170 amino acids
Theoretical weight: 19.04 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q16611 (Residues: 23-186; Coverage: 78%)
  • Best match: Q16611-2 (Residues: 23-116)
Gene names: BAK, BAK1, BCL2L7, CDN1
Sequence domains: Apoptosis regulator proteins, Bcl-2 family
DM2 peptide Chain: B
Molecule details ›
Chain: B
Length: 25 amino acids
Theoretical weight: 2.7 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: C2
Unit cell:
a: 102.13Å b: 41.04Å c: 47.02Å
α: 90° β: 93.64° γ: 90°
R-values:
R R work R free
0.18 0.178 0.2
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

1 review citation

Mechanisms of BCL-2 family proteins in mitochondrial apoptosis.
Czabotar et al. (2023)
1 other article

1 mention without citation

Peptides from human BNIP5 and PXT1 and non-native binders of pro-apoptotic BAK can directly activate or inhibit BAK-mediated membrane permeabilization.
Aguilar et al. (2023)

PDB-REDO

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