› 8d0c

X-ray diffraction
2.09Å resolution

Function and Biology Details

Reaction catalysed: 
(1a) NAD(+) = cyclic ADP-ribose + nicotinamide
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-564531 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
NAD(+) hydrolase SARM1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 143 amino acids
Theoretical weight: 16.21 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q6SZW1 (Residues: 558-700; Coverage: 20%)
Gene names: KIAA0524, SAMD2, SARM, SARM1
Sequence domains: TIR domain

Ligands and Environments

1 bound ligand:
Ligand Q1F 2 x Q1F
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.3.1
Spacegroup: P21212
Unit cell:
a: 87.086Å b: 117.23Å c: 32.865Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.18 0.176 0.223
Expression system: Escherichia coli

Quick links

Citations

5 review citations

NAD+, Axonal Maintenance, and Neurological Disease.
Alexandris et al. (2023)
4 more