› 8d1g

Electron Microscopy
2.07Å resolution

hBest2 Ca2+-bound open state

Released:
DOI: 10.2210/pdb8d1g/pdb
PDB entry 8d1g coloured by chain, front view.
PDB entry 8d1g coloured by chain, side view.
PDB entry 8d1g coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structures and gating mechanisms of human bestrophin anion channels.
Owji AP, Wang J, Kittredge A, Clark Z, Zhang Y, Hendrickson WA, Yang T
OpenAccess logo Nat Commun 13 3836 (2022)
PMID: 35789156
Related structures: EMD-27129

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo pentamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-185538 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bestrophin-2a Chains: A, B, C, D, E
Molecule details ›
Chains: A, B, C, D, E
Length: 406 amino acids
Theoretical weight: 46.8 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q8NFU1 (Residues: 1-406; Coverage: 80%)
Gene names: BEST2, VMD2L1
Sequence domains: Bestrophin, RFP-TM, chloride channel

Ligands and Environments

4 bound ligands:
Ligand CA 5 x CA
Ligand DU0 5 x DU0
Ligand MC3 50 x MC3
Ligand CL 1 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.07Å
Relevant EMDB volumes: EMD-27129
Expression system: Homo sapiens

Quick links

Citations

1 review citation

GABA Release from Astrocytes in Health and Disease.
Kilb et al. (2022)
5 other articles