› 8d1i

Electron Microscopy
1.82Å resolution

hBest1 1uM Ca2+ (Ca2+-bound) closed state

Released:
DOI: 10.2210/pdb8d1i/pdb
PDB entry 8d1i coloured by chain, front view.
PDB entry 8d1i coloured by chain, side view.
PDB entry 8d1i coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structures and gating mechanisms of human bestrophin anion channels.
Owji AP, Wang J, Kittredge A, Clark Z, Zhang Y, Hendrickson WA, Yang T
OpenAccess logo Nat Commun 13 3836 (2022)
PMID: 35789156
Related structures: EMD-27131

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo pentamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131213 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bestrophin-1 Chains: A, B, C, D, E
Molecule details ›
Chains: A, B, C, D, E
Length: 585 amino acids
Theoretical weight: 67.76 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: O76090 (Residues: 1-585; Coverage: 100%)
Gene names: BEST1, VMD2
Sequence domains: Bestrophin, RFP-TM, chloride channel

Ligands and Environments

2 bound ligands:
Ligand CA 5 x CA
Ligand MC3 40 x MC3
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 1.82Å
Relevant EMDB volumes: EMD-27131
Expression system: Homo sapiens

Quick links

Citations

1 review citation

GABA Release from Astrocytes in Health and Disease.
Kilb et al. (2022)
5 other articles

3 mentions without citation

Variants of BEST1 and CRYBB2 cause a complex ocular phenotype comprising microphthalmia, microcornea, cataract, and vitelliform macular dystrophy: case report.
Shi et al. (2023)
2 more