› 8d1k

Electron Microscopy
2.28Å resolution

hBest1 Ca2+-bound partially open neck state

Released:
DOI: 10.2210/pdb8d1k/pdb
PDB entry 8d1k coloured by chain, front view.
PDB entry 8d1k coloured by chain, side view.
PDB entry 8d1k coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structures and gating mechanisms of human bestrophin anion channels.
Owji AP, Wang J, Kittredge A, Clark Z, Zhang Y, Hendrickson WA, Yang T
OpenAccess logo Nat Commun 13 3836 (2022)
PMID: 35789156
Related structures: EMD-27133

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo pentamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131213 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bestrophin-1 Chains: A, B, C, D, E
Molecule details ›
Chains: A, B, C, D, E
Length: 585 amino acids
Theoretical weight: 67.76 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: O76090 (Residues: 1-585; Coverage: 100%)
Gene names: BEST1, VMD2
Sequence domains: Bestrophin, RFP-TM, chloride channel

Ligands and Environments

2 bound ligands:
Ligand CA 5 x CA
Ligand MC3 40 x MC3
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.28Å
Relevant EMDB volumes: EMD-27133
Expression system: Homo sapiens

Quick links

Citations

1 review citation

GABA Release from Astrocytes in Health and Disease.
Kilb et al. (2022)
5 other articles

1 mention without citation

Electronic Polarizability Tunes the Function of the Human Bestrophin 1 Cl⁻ Channel.
Phan et al. (2023)