› 8d2s

Electron Microscopy
2.9Å resolution

Zebrafish MFSD2A isoform B in inward open ligand bound conformation

Released:
DOI: 10.2210/pdb8d2s/pdb
PDB entry 8d2s coloured by chain, front view.
PDB entry 8d2s coloured by chain, side view.
PDB entry 8d2s coloured by chain, top view.
Source organisms:
Primary publication:
Lipid flipping in the omega-3 fatty-acid transporter.
Nguyen C, Lei HT, Lai LTF, Gallenito MJ, Mu X, Matthies D, Gonen T
OpenAccess logo Nat Commun 14 2571 (2023)
PMID: 37156797
Related structures: EMD-27148

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-280064 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Sodium-dependent lysophosphatidylcholine symporter 1-B Chain: A
Molecule details ›
Chain: A
Length: 508 amino acids
Theoretical weight: 56.68 KDa
Source organism: Danio rerio
Expression system: Spodoptera frugiperda
FAB light chain Chain: B
Molecule details ›
Chain: B
Length: 201 amino acids
Theoretical weight: 20.67 KDa
Source organism: Mus musculus
Expression system: Mus musculus
FAB heavy chain Chain: C

Ligands and Environments

3 bound ligands:
Ligand ZGS 3 x ZGS
Ligand LMT 17 x LMT
Ligand NA 1 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.9Å
Relevant EMDB volumes: EMD-27148
Expression systems:
  • Spodoptera frugiperda
  • Mus musculus

Quick links

Citations

6 citation in other articles

Structural basis of Sphingosine-1-phosphate transport via human SPNS2.
Duan et al. (2024)
5 more

1 mention without citation

Lipid flipping in the omega-3 fatty-acid transporter.
Nguyen et al. (2023)