› › Structure analysis

Zebrafish MFSD2A isoform B in inward open ligand bound conformation

Electron Microscopy
2.9Å resolution
PDB entry 8d2s coloured by chain, front view.
PDB entry 8d2s coloured by chain, side view.
PDB entry 8d2s coloured by chain, top view.
Source organisms:
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

Quick links

Assemblies

Assembly 1 (preferred)
Download    3D Visualisation
Assembly Name: Sodium-dependent lysophosphatidylcholine symporter 1-B
hide full assembly name
Multimeric state: hetero trimer
Accessible surface area: 36584.95 Å2
Buried surface area: 16023.82 Å2
Dissociation area: 1,710.75 Å2
Dissociation energy (ΔGdiss): -5.55 kcal/mol
Dissociation entropy (TΔSdiss): 14.07 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-280064

Macromolecules

Sodium-dependent lysophosphatidylcholine symporter 1-B
Chain: A
Length: 508 amino acids
Theoretical weight: 56.68 KDa
Source organism: Danio rerio
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q6DEJ6 (Residues: 22-509; Coverage: 93%)
Gene names: mfsd2ab, nls1b, si:ch211-194e15.3, si:ch211-210b19.5
Pfam: MFS/sugar transport protein
Sodium-dependent lysophosphatidylcholine symporter 1-B in PDB entry 8d2s, assembly 1, front view.
Sodium-dependent lysophosphatidylcholine symporter 1-B in PDB entry 8d2s, assembly 1, side view.
Sodium-dependent lysophosphatidylcholine symporter 1-B in PDB entry 8d2s, assembly 1, top view.
PDBe-KB: UniProt Coverage View: Q6DEJ6  
150850100150200250300350400450500
 
200400MHHHHHHHHHHENLYFQGGSDEVKLAKHETKSRLSVCSKLCYAIGGAPYQITGCAIGFFLQIYLLDVALLDPFYASIILFVGRAWDAVTDPTVGFLVSRTPWTRFGRMMPWIVLSTPFAVLCYFLIWYVPSVDQGKVVWYLIFYCCFQTLQTCFHVPYSALTMFISTEQKERDSATAYRMTVEVLGTLIGTAIQGQIVGMANAPCISTEIDLQSTGLEVAPDVQITDPHVSLQDLRNAYMIASGVICAIYVVCAVVLFLGVKEQKDTCRVRTEPMSFFQGICMVMGHGPYAKLVMGFLFTSLAFMLLEGNFALFCIYNLGFRNDFQNVLLVIMLSATLAIPFWQWFLTKFGKKTAVYIGTTSVVPFLISVVLVPSSLAVTYIASFAAGVSVAAAFLLPWSMLPDVVDDFKVQNPESQGHEAIFYSFYVFFTKFASGVSLGVSTLSLDFAGYVTRGCTQPGEVKLTLKILVSAAPIVLIIIGLLIFISYPINEEKRQGNRKLLNEQREQ
UniProt
Q6DEJ6
Chains
Secondary structure
Flexibility predictions
Ligand binding sites
Sequence conservation
Molecule details ›

Search similar proteins

FAB light chain
Chain: B
Length: 201 amino acids
Theoretical weight: 20.67 KDa
Source organism: Mus musculus
Expression system: Mus musculus
FAB light chain in PDB entry 8d2s, assembly 1, front view.
FAB light chain in PDB entry 8d2s, assembly 1, side view.
FAB light chain in PDB entry 8d2s, assembly 1, top view.
120120406080100120140160180200
 
50100150200ALDINSPEAEKNAKGARARITCNAGNQVGSAVAWFNQRPGDPASLLTYWAATEKGVAGKQSAQGASTKFSMSSAGPEAPSLSSYWCLLFEKGAFSFGGSKLNPREGAGPQASILPPSADLNTSGGAAVVCFLPNWYGNITVQWKTEAPQSQANMSWPGQAGANAAYAMAAVLAITKGDYGPGSFTCNASNRGTGPFAMSLN
Chains
Chain B (auth B)
Secondary structure
Ligand binding sites
Interaction interfaces
Sequence conservation
Molecule details ›

Search similar proteins

FAB heavy chain
Chain: C
Length: 203 amino acids
Theoretical weight: 20.57 KDa
Source organism: Mus musculus
Expression system: Mus musculus
FAB heavy chain in PDB entry 8d2s, assembly 1, front view.
FAB heavy chain in PDB entry 8d2s, assembly 1, side view.
FAB heavy chain in PDB entry 8d2s, assembly 1, top view.
120320406080100120140160180200
 
50100150200ASKLELSGPAEPRGSKSAQITCKAKGFPEARFWVFWLFQRAAALDWPAANFSGGPVQFESRFQGNASLKGSQAQANAELNIGALGSSTATYRCGWKLANGGFFPSWGGANVNGAAGAKAPAVYPVEISGAGTGSVTLGCLVKGYNAKPNLTWPGASGALTFPSELNGALWNLASAVTGSGFPSATCAVGFGAATDVDKKVAAA
Chains
Chain C (auth C)
Secondary structure
Ligand binding sites
Interaction interfaces
Sequence conservation
Molecule details ›

Search similar proteins

Quick links