› 8d2t

Electron Microscopy
3.4Å resolution

Zebrafish MFSD2A isoform B in inward open ligand-free conformation

Released:
DOI: 10.2210/pdb8d2t/pdb
PDB entry 8d2t coloured by chain, front view.
PDB entry 8d2t coloured by chain, side view.
PDB entry 8d2t coloured by chain, top view.
Source organisms:
Primary publication:
Lipid flipping in the omega-3 fatty-acid transporter.
Nguyen C, Lei HT, Lai LTF, Gallenito MJ, Mu X, Matthies D, Gonen T
OpenAccess logo Nat Commun 14 2571 (2023)
PMID: 37156797
Related structures: EMD-27149

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-216384 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Sodium-dependent lysophosphatidylcholine symporter 1-B Chain: A
Molecule details ›
Chain: A
Length: 508 amino acids
Theoretical weight: 56.68 KDa
Source organism: Danio rerio
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q6DEJ6 (Residues: 22-509; Coverage: 93%)
Gene names: mfsd2ab, nls1b, si:ch211-194e15.3, si:ch211-210b19.5
Sequence domains: MFS/sugar transport protein
FAB light chain Chain: B
Molecule details ›
Chain: B
Length: 201 amino acids
Theoretical weight: 20.67 KDa
Source organism: Mus musculus
Expression system: Mus musculus
FAB heavy chain Chain: C
Molecule details ›
Chain: C
Length: 203 amino acids
Theoretical weight: 20.57 KDa
Source organism: Mus musculus
Expression system: Mus musculus

Ligands and Environments

1 bound ligand:
Ligand LMT 10 x LMT
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.4Å
Relevant EMDB volumes: EMD-27149
Expression systems:
  • Spodoptera frugiperda
  • Mus musculus

Quick links

Citations

2 citation in other articles

Knockdown of Placental Major Facilitator Superfamily Domain Containing 2a in Pregnant Mice Reduces Fetal Brain Growth and Phospholipid Docosahexaenoic Acid Content.
Powell et al. (2023)
1 more

1 mention without citation

Lipid flipping in the omega-3 fatty-acid transporter.
Nguyen et al. (2023)