› 8d3b

X-ray diffraction
3.3Å resolution

Hexameric HIV-1 (M-group) Q50Y/R120 mutant

Released:
DOI: 10.2210/pdb8d3b/pdb
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PDB entry 8d3b coloured by chain, front view.
PDB entry 8d3b coloured by chain, side view.
PDB entry 8d3b coloured by chain, top view.
Source organism: Human immunodeficiency virus 1
Primary publication:
Evasion of cGAS and TRIM5 defines pandemic HIV.
Zuliani-Alvarez L, Govasli ML, Rasaiyaah J, Monit C, Perry SO, Sumner RP, McAlpine-Scott S, Dickson C, Rifat Faysal KM, Hilditch L, Miles RJ, Bibollet-Ruche F, Hahn BH, Boecking T, Pinotsis N, James LC, Jacques DA, Towers GJ
OpenAccess logo Nat Microbiol 7 1762-1776 (2022)
PMID: 36289397

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-273627 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Capsid protein p24 Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 232 amino acids
Theoretical weight: 25.65 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P35962 (Residues: 133-251, 252-363; Coverage: 46%)
Gene name: gag
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: RIGAKU FR-E SUPERBRIGHT
Spacegroup: C2
Unit cell:
a: 90.92Å b: 157.31Å c: 120.4Å
α: 90° β: 107.28° γ: 90°
R-values:
R R work R free
0.241 0.239 0.275
Expression system: Escherichia coli BL21(DE3)

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Citations

7 review citations

Function and regulation of cGAS-STING signaling in infectious diseases.
Du et al. (2023)
6 more

1 mention without citation

Evasion of cGAS and TRIM5 defines pandemic HIV.
Zuliani-Alvarez et al. (2022)

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