› 8d4y

X-ray diffraction
2.9Å resolution

C-terminal SANT-SLIDE domain of human Chromodomain-helicase-DNA-binding protein 4 (CHD4)

Released:
DOI: 10.2210/pdb8d4y/pdb
PDB entry 8d4y coloured by chain, front view.
PDB entry 8d4y coloured by chain, side view.
PDB entry 8d4y coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The role of auxiliary domains in modulating CHD4 activity suggests mechanistic commonality between enzyme families.
Zhong Y, Moghaddas Sani H, Paudel BP, Low JKK, Silva APG, Mueller S, Deshpande C, Panjikar S, Reid XJ, Bedward MJ, van Oijen AM, Mackay JP
OpenAccess logo Nat Commun 13 7524 (2022)
PMID: 36473839

Function and Biology Details

Reaction catalysed: 
ATP + H(2)O = ADP + phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172109 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Chromodomain-helicase-DNA-binding protein 4 Chains: A, B
Molecule details ›
Chains: A, B
Length: 431 amino acids
Theoretical weight: 49.27 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q14839 (Residues: 1380-1810; Coverage: 23%)
Gene name: CHD4
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: P21
Unit cell:
a: 65.432Å b: 66.665Å c: 99.37Å
α: 90° β: 100.77° γ: 90°
R-values:
R R work R free
0.265 0.263 0.301
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Protein disorder and autoinhibition: The role of multivalency and effective concentration.
Fenton et al. (2023)
1 other article

1 mention without citation

The role of auxiliary domains in modulating CHD4 activity suggests mechanistic commonality between enzyme families.
Zhong et al. (2022)