› 8d6d

X-ray diffraction
2.35Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189237 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase Chains: A, B
Molecule details ›
Chains: A, B
Length: 311 amino acids
Theoretical weight: 34.5 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q99640 (Residues: 75-362; Coverage: 58%)
Gene names: MYT1, PKMYT1
Sequence domains: Protein kinase domain

Ligands and Environments

3 bound ligands:
Ligand EDO 5 x EDO
Ligand SO4 2 x SO4
Ligand QGY 2 x QGY
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P21
Unit cell:
a: 51.46Å b: 112.92Å c: 72.66Å
α: 90° β: 110.34° γ: 90°
R-values:
R R work R free
0.242 0.241 0.272
Expression system: Escherichia coli

Quick links

Citations

1 review citation

A new wave of innovations within the DNA damage response.
Li et al. (2023)
2 other articles

1 mention without citation

Discovery of an Orally Bioavailable and Selective PKMYT1 Inhibitor, RP-6306.
Szychowski et al. (2022)