› 8d7o

X-ray diffraction
1.65Å resolution

Human Casein kinase 1 delta in complex with phosphorylated human PERIOD2 FASP peptide

Released:
DOI: 10.2210/pdb8d7o/pdb
Model geometry
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PDB entry 8d7o coloured by chain, front view.
PDB entry 8d7o coloured by chain, side view.
PDB entry 8d7o coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
PERIOD phosphorylation leads to feedback inhibition of CK1 activity to control circadian period.
Philpott JM, Freeberg AM, Park J, Lee K, Ricci CG, Hunt SR, Narasimamurthy R, Segal DH, Robles R, Cai Y, Tripathi S, McCammon JA, Virshup DM, Chiu JC, Lee C, Partch CL
Mol Cell 83 1677-1692.e8 (2023)
PMID: 37207626

Function and Biology Details

Reactions catalysed: 
ATP + a protein = ADP + a phosphoprotein
ATP + [tau protein] = ADP + [tau protein] phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-271576 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Casein kinase I isoform delta Chains: A, B
Molecule details ›
Chains: A, B
Length: 301 amino acids
Theoretical weight: 34.95 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P48730 (Residues: 1-294; Coverage: 71%)
Gene names: CSNK1D, HCKID
Sequence domains: Protein kinase domain
Period circadian protein homolog 2 Chains: C, D
Molecule details ›
Chains: C, D
Length: 16 amino acids
Theoretical weight: 1.92 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: O15055 (Residues: 658-673; Coverage: 1%)
Gene names: KIAA0347, PER2

Ligands and Environments

No bound ligands
1 modified residue:
Ligand SEP 8 x SEP

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: APS BEAMLINE 23-ID-D
Spacegroup: C2
Unit cell:
a: 55.33Å b: 135.4Å c: 90.351Å
α: 90° β: 94.41° γ: 90°
R-values:
R R work R free
0.174 0.172 0.209
Expression systems:
  • Escherichia coli
  • Not provided

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Citations

3 review citations

Interorgan rhythmicity as a feature of healthful metabolism.
Bass J. (2024)
2 more

1 mention without citation

Isoform-specific C-terminal phosphorylation drives autoinhibition of Casein Kinase 1.
Harold et al. (2024)

PDB-REDO

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