Function and Biology Details
Biochemical function:
Biological process:
Cellular component:
Structure analysis Details
Assembly composition:
hetero hexamer (preferred)
Assembly name:
Interleukin-6 antagonist complex (preferred)
PDBe Complex ID:
PDB-CPX-138620 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (4 distinct):
Soluble interleukin-6 receptor subunit alpha
Molecule details ›
Chains: C, G
Length: 346 amino acids
Theoretical weight: 38.69 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
Sequence domains:
Length: 346 amino acids
Theoretical weight: 38.69 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
- Canonical:
P08887 (Residues: 20-331; Coverage: 70%)
Sequence domains:
Interleukin-6
Molecule details ›
Chains: D, H
Length: 183 amino acids
Theoretical weight: 20.84 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Interleukin-6/G-CSF/MGF family
Length: 183 amino acids
Theoretical weight: 20.84 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: P05231 (Residues: 30-212; Coverage: 100%)
Sequence domains: Interleukin-6/G-CSF/MGF family
Interleukin-6 receptor subunit beta
Molecule details ›
Chains: A, E
Length: 678 amino acids
Theoretical weight: 77.09 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Sequence domains:
Length: 678 amino acids
Theoretical weight: 77.09 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical: P40189 (Residues: 23-700; Coverage: 76%)
Sequence domains:
