8d8o

Electron Microscopy
3.35Å resolution

Cryo-EM structure of substrate unbound PAPP-A

Released:
Source organism: Homo sapiens
Entry authors: Judge RA, Jain R, Hao Q, Ouch C, Sridar J, Smith CL, Wang JCK, Eaton D
Related structures: EMD-27253

Function and Biology Details

Reaction catalysed:
Cleavage of the 135-Met-|-Lys-136 bond in insulin-like growth factor binding protein (IGFBP)-4, and the 143-Ser-|-Lys-144 bond in IGFBP-5.
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171606 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Pappalysin-1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 1581 amino acids
Theoretical weight: 176.34 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q13219 (Residues: 81-1627; Coverage: 96%)
Gene name: PAPPA
Sequence domains:

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.35Å
Relevant EMDB volumes: EMD-27253
Expression system: Homo sapiens