Function and Biology Details
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Small GTPase superfamily, ARF/SAR type
- Clathrin adaptor, mu subunit
- HIV-1 Nef protein, core domain superfamily
- HIV negative factor Nef
- P-loop containing nucleoside triphosphate hydrolase
- Adaptor protein complex, sigma subunit
- Mu homology domain
- Clathrin adaptor, mu subunit, conserved site
22 more domains
Structure analysis Details
Assembly composition:
hetero octadecamer (preferred)
PDBe Complex ID:
PDB-CPX-269627 (preferred)
Entry contents:
7 distinct polypeptide molecules
Macromolecules (7 distinct):
ADP-ribosylation factor
Molecule details ›
Chains: C, D, F, H
Length: 181 amino acids
Theoretical weight: 20.72 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
Sequence domains: ADP-ribosylation factor family
Length: 181 amino acids
Theoretical weight: 20.72 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical:
A0A8C2UGL4 (Residues: 1-181; Coverage: 100%)
Sequence domains: ADP-ribosylation factor family
Protein Nef
Molecule details ›
Chains: I, K, L, N
Length: 213 amino acids
Theoretical weight: 24.29 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Escherichia coli BL21(DE3)
UniProt:
Sequence domains: Negative factor, (F-Protein) or Nef
Length: 213 amino acids
Theoretical weight: 24.29 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical: Q90VU7 (Residues: 1-206; Coverage: 100%)
Sequence domains: Negative factor, (F-Protein) or Nef
HLA class I histocompatibility antigen, A alpha chain
AP-1 complex subunit beta-1
AP-1 complex subunit gamma-1
AP-1 complex subunit mu-1
AP-1 complex subunit sigma-3
