› 8dam

X-ray diffraction
2Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-275184 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Voltage-dependent L-type calcium channel subunit beta-1 Chain: A
Molecule details ›
Chain: A
Length: 370 amino acids
Theoretical weight: 41.29 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8R3Z5 (Residues: 58-427; Coverage: 62%)
Gene names: Cacnb1, Cacnlb1
Sequence domains:
nanobody F3 Chain: B
Molecule details ›
Chain: B
Length: 123 amino acids
Theoretical weight: 13.45 KDa
Source organism: Lama glama
Expression system: Escherichia coli
Nanobody E8 Chain: C

Ligands and Environments

2 bound ligands:
Ligand SO4 4 x SO4
Ligand MPD 1 x MPD
1 modified residue:
Ligand MSE 2 x MSE

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: ALS BEAMLINE 8.3.1
Spacegroup: P212121
Unit cell:
a: 80.358Å b: 81.072Å c: 93.332Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.195 0.193 0.227
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Peptide and Peptidomimetic Inhibitors Targeting the Interaction of Collapsin Response Mediator Protein 2 with the N-Type Calcium Channel for Pain Relief.
Perez-Miller et al. (2024)
2 other articles