8dan

Electron Microscopy
4.74Å resolution

CryoEM structure of Western equine encephalitis virus VLP in complex with the avian MXRA8 receptor

Released:
Entry authors: Zimmerman MI, Fremont DH, Center for Structural Genomics of Infectious Diseases (CSGID), Center for Structural Biology of Infectious Diseases (CSBID)
Related structures: EMD-27271

Function and Biology Details

Reaction catalysed:
Autocatalytic release of the core protein from the N-terminus of the togavirus structural polyprotein by hydrolysis of a -Trp-|-Ser- bond.
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero dodecamer (preferred)
PDBe Complex ID:
PDB-CPX-269567 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
p130 Chains: A, D, G, J
Molecule details ›
Chains: A, D, G, J
Length: 438 amino acids
Theoretical weight: 47.19 KDa
Source organism: Western equine encephalitis virus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q1W679 (Residues: 798-1235; Coverage: 35%)
Sequence domains: Alphavirus E1 glycoprotein
p130 Chains: B, E, H, K
Molecule details ›
Chains: B, E, H, K
Length: 415 amino acids
Theoretical weight: 46.17 KDa
Source organism: Western equine encephalitis virus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q1W679 (Residues: 321-735; Coverage: 34%)
Sequence domains: Alphavirus E2 glycoprotein
Matrix remodeling-associated protein 8 Chains: C, F, I, L

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.74Å
Relevant EMDB volumes: EMD-27271
Expression system: Homo sapiens