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RNA ligase RtcB from Pyrococcus horikoshii in complex with Ni2+ and GTP

Source organism: Pyrococcus horikoshii OT3
Biochemical function: RNA ligase activity
Biological process: RNA processing
Cellular component: not assigned

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EC 6.5.1.8: 3'-phosphate/5'-hydroxy nucleic acid ligase

Reaction catalysed:
(1a) GTP + [RNA ligase]-L-histidine = 5'-guanosyl [RNA ligase]-N(tau)-phosphono-L-histidine + diphosphate
Systematic name:
Poly(ribonucleotide)-3'-phosphate:5'-hydroxy-poly(ribonucleotide) ligase (GMP-forming)
Alternative Name(s):
  • RtcB (gene name)

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF01139
Domain description: tRNA-splicing ligase RtcB
Occurring in:
  1. Pho hyp2 intein
The deposited structure of PDB entry 8dcb contains 2 copies of Pfam domain PF01139 (tRNA-splicing ligase RtcB) in Pho hyp2 intein. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR036025
Domain description: tRNA-splicing ligase RtcB-like superfamily
Occurring in:
  1. Pho hyp2 intein
IPR001233
Domain description: RNA-splicing ligase, RtcB
Occurring in:
  1. Pho hyp2 intein
IPR014729
Domain description: Rossmann-like alpha/beta/alpha sandwich fold
Occurring in:
  1. Pho hyp2 intein

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