8der

Electron Microscopy
3.3Å resolution

Cryo-EM local refinement of antibody SKV16 in complex with VEEV alphavirus spike glycoprotein

Released:

Function and Biology Details

Reaction catalysed:
Autocatalytic release of the core protein from the N-terminus of the togavirus structural polyprotein by hydrolysis of a -Trp-|-Ser- bond.
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dodecamer (preferred)
PDBe Complex ID:
PDB-CPX-272343 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (6 distinct):
SKV16 Fab Heavy Chain Chains: H, W, X
Molecule details ›
Chains: H, W, X
Length: 122 amino acids
Theoretical weight: 13.46 KDa
Source organism: Macaca
Expression system: Homo sapiens
SKV16 Fab Light Chain Chains: L, V, Y
Molecule details ›
Chains: L, V, Y
Length: 105 amino acids
Theoretical weight: 11.21 KDa
Source organism: Macaca
Expression system: Homo sapiens
Spike glycoprotein E1 Chains: E, F, G
Spike glycoprotein E2 Chains: A, B, C

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer : NEW Components: NAG, BMA
1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.3Å
Relevant EMDB volumes: EMD-27396
Expression system: Homo sapiens