› 8dh9

Electron Microscopy
4.5Å resolution

Leptin-bound leptin receptor complex-D3-D7

Released:
DOI: 10.2210/pdb8dh9/pdb
PDB entry 8dh9 coloured by chain, front view.
PDB entry 8dh9 coloured by chain, side view.
PDB entry 8dh9 coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structural insights into the mechanism of leptin receptor activation.
Saxton RA, Caveney NA, Moya-Garzon MD, Householder KD, Rodriguez GE, Burdsall KA, Long JZ, Garcia KC
OpenAccess logo Nat Commun 14 1797 (2023)
PMID: 37002197
Related structures: EMD-27433

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-211195 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Leptin receptor Chains: A, B
Molecule details ›
Chains: A, B
Length: 557 amino acids
Theoretical weight: 63.67 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: P48356 (Residues: 328-839; Coverage: 45%)
  • Best match: P48356-5 (Residues: 328-796)
Gene names: Db, Lepr, Obr
Sequence domains:
Leptin Chains: C, D
Molecule details ›
Chains: C, D
Length: 167 amino acids
Theoretical weight: 18.72 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: P41160 (Residues: 1-167; Coverage: 100%)
Gene names: Lep, Ob
Sequence domains: Leptin

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.5Å
Relevant EMDB volumes: EMD-27433
Expression system: Homo sapiens

Quick links

Citations

1 citations in other articles

Impact of hs-CRP concentration on brain structure alterations and cognitive trajectory in Alzheimer's disease.
Zhang et al. (2023)

1 mention without citation

Structural insights into the mechanism of leptin receptor activation.
Saxton et al. (2023)