› 8dha

Electron Microscopy
3.8Å resolution

Leptin-bound leptin receptor complex- focused interaction

Released:
DOI: 10.2210/pdb8dha/pdb
PDB entry 8dha coloured by chain, front view.
PDB entry 8dha coloured by chain, side view.
PDB entry 8dha coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structural insights into the mechanism of leptin receptor activation.
Saxton RA, Caveney NA, Moya-Garzon MD, Householder KD, Rodriguez GE, Burdsall KA, Long JZ, Garcia KC
OpenAccess logo Nat Commun 14 1797 (2023)
PMID: 37002197
Related structures: EMD-27434

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-199873 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Leptin receptor Chains: A, B
Molecule details ›
Chains: A, B
Length: 555 amino acids
Theoretical weight: 63.45 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: P48356 (Residues: 330-839; Coverage: 45%)
  • Best match: P48356-5 (Residues: 330-796)
Gene names: Db, Lepr, Obr
Sequence domains:
Leptin Chain: C
Molecule details ›
Chain: C
Length: 146 amino acids
Theoretical weight: 16.02 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: P41160 (Residues: 22-167; Coverage: 100%)
Gene names: Lep, Ob
Sequence domains: Leptin

Ligands and Environments

1 bound ligand:
Ligand NAG 2 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.8Å
Relevant EMDB volumes: EMD-27434
Expression system: Homo sapiens

Quick links

Citations

3 review citations

From Marrow to Bone and Fat: Exploring the Multifaceted Roles of Leptin Receptor Positive Bone Marrow Mesenchymal Stromal Cells.
Prasad et al. (2024)
2 more

1 mention without citation

Structural insights into the mechanism of leptin receptor activation.
Saxton et al. (2023)