› 8dhc

X-ray diffraction
2.02Å resolution

Crystal structure of an i-motif from the HRAS promoter region

Released:
DOI: 10.2210/pdb8dhc/pdb
PDB entry 8dhc coloured by chain, front view.
PDB entry 8dhc coloured by chain, side view.
PDB entry 8dhc coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal Structure of an i-Motif from the HRAS Oncogene Promoter.
Li KS, Jordan D, Lin LY, McCarthy SE, Schneekloth JS, Yatsunyk LA
Angew Chem Int Ed Engl e202301666 (2023)
PMID: 36995904

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-215350 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
HRAS DNA Chains: A, B
Molecule details ›
Chains: A, B
Length: 27 nucleotides
Theoretical weight: 8.15 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand PG5 1 x PG5
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: C2
Unit cell:
a: 119.126Å b: 29.656Å c: 54.326Å
α: 90° β: 93.1° γ: 90°
R-values:
R R work R free
0.252 0.252 0.254
Expression system: Not provided

Quick links

Citations

1 mention without citation

Effect of psychotropic drug treatment on sterol metabolism.
Korade et al. (2017)