› 8dmy

Electron Microscopy
3.07Å resolution

Cryo-EM structure of cardiac muscle alpha-actin

Released:
DOI: 10.2210/pdb8dmy/pdb
PDB entry 8dmy coloured by chain, front view.
PDB entry 8dmy coloured by chain, side view.
PDB entry 8dmy coloured by chain, top view.
Source organism: Bos taurus
Primary publication:
Structural insights into actin isoforms.
Arora AS, Huang HL, Singh R, Narui Y, Suchenko A, Hatano T, Heissler SM, Balasubramanian MK, Chinthalapudi K
Elife 12 (2023)
PMID: 36790143
Related structures: EMD-27549

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-199934 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Actin, alpha cardiac muscle 1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 374 amino acids
Theoretical weight: 41.73 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: Q3ZC07 (Residues: 4-377; Coverage: 99%)
Gene names: ACTC, ACTC1
Sequence domains: Actin

Ligands and Environments

2 bound ligands:
Ligand ADP 4 x ADP
Ligand MG 4 x MG
1 modified residue:
Ligand HIC 4 x HIC

Experiments and Validation Details

Entry percentile scores
Resolution: 3.07Å
Relevant EMDB volumes: EMD-27549

Quick links

Citations

1 review citation

Nucleus Mechanosensing in Cardiomyocytes.
Coscarella et al. (2023)
3 other articles

1 mention without citation

Structural insights into actin isoforms.
Arora et al. (2023)