› 8dng

Electron Microscopy
3Å resolution

Prefusion-stabilized Nipah virus fusion protein

Released:
DOI: 10.2210/pdb8dng/pdb
PDB entry 8dng coloured by chain, front view.
PDB entry 8dng coloured by chain, side view.
PDB entry 8dng coloured by chain, top view.
Source organism: Henipavirus nipahense
Primary publication:
Prefusion stabilization of the Hendra and Langya virus F proteins.
Byrne PO, Blade EG, Fisher BE, Ambrozak DR, Ramamohan AR, Graham BS, Loomis RJ, McLellan JS
J Virol e0137223 (2024)
PMID: 38214525
Related structures: EMD-27566

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-191531 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Fusion glycoprotein F1 Chains: A, D, G
Molecule details ›
Chains: A, D, G
Length: 442 amino acids
Theoretical weight: 48.5 KDa
Source organism: Henipavirus nipahense
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9IH63 (Residues: 27-468; Coverage: 85%)
Gene name: F
Sequence domains: Fusion glycoprotein F0

Ligands and Environments

1 bound ligand:
Ligand NAG 12 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3Å
Relevant EMDB volumes: EMD-27566
Expression system: Homo sapiens

Quick links

Citations

4 citation in other articles

A monoclonal antibody targeting the Nipah virus fusion glycoprotein apex imparts protection from disease.
Avanzato et al. (2024)
3 more