› 8dnu

Electron Microscopy
2.73Å resolution

Human Brain Glutamine Synthetase

Released:
DOI: 10.2210/pdb8dnu/pdb
PDB entry 8dnu coloured by chain, front view.
PDB entry 8dnu coloured by chain, side view.
PDB entry 8dnu coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
A cryo-electron microscopic approach to elucidate protein structures from human brain microsomes.
Tringides ML, Zhang Z, Morgan CE, Su CC, Yu EW
OpenAccess logo Life Sci Alliance 6 (2023)
PMID: 36450447
Related structures: EMD-27580

Function and Biology Details

Reactions catalysed: 
Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA
ATP + L-glutamate + NH(3) = ADP + phosphate + L-glutamine
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo decamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-147217 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutamine synthetase Chains: A, B, C, D, E, F, G, H, I, J
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J
Length: 373 amino acids
Theoretical weight: 42.12 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P15104 (Residues: 1-373; Coverage: 100%)
Gene names: GLNS, GLUL
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand MN 10 x MN
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.73Å
Relevant EMDB volumes: EMD-27580

Quick links

Citations

1 citations in other articles

High-Resolution Structural Proteomics of Mitochondria Using the 'Build and Retrieve' Methodology.
Zhang et al. (2023)

1 mention without citation

A cryo-electron microscopic approach to elucidate protein structures from human brain microsomes.
Tringides et al. (2023)