8dny

Electron Microscopy
2.85Å resolution

Cryo-EM structure of the human Sec61 complex inhibited by decatransin

Released:

Function and Biology Details

Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
PDBe Complex ID:
PDB-CPX-274020 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Protein transport protein Sec61 subunit alpha isoform 1 Chain: A
Molecule details ›
Chain: A
Length: 476 amino acids
Theoretical weight: 52.2 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P61619 (Residues: 1-476; Coverage: 100%)
Gene names: SEC61A, SEC61A1
Sequence domains:
Protein transport protein Sec61 subunit gamma Chain: B
Molecule details ›
Chain: B
Length: 68 amino acids
Theoretical weight: 7.75 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P60059 (Residues: 1-68; Coverage: 100%)
Gene name: SEC61G
Sequence domains: SecE/Sec61-gamma subunits of protein translocation complex
Protein transport protein Sec61 subunit beta Chain: C
Molecule details ›
Chain: C
Length: 96 amino acids
Theoretical weight: 9.99 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P60468 (Residues: 1-96; Coverage: 100%)
Gene name: SEC61B
Sequence domains: Sec61beta family
Decatransin peptide inhibitor Chain: D
Molecule details ›
Chain: D
Length: 10 amino acids
Theoretical weight: 1.2 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

No bound ligands
3 modified residues:

Experiments and Validation Details

Entry percentile scores
Resolution: 2.85Å
Relevant EMDB volumes: EMD-27584
Expression systems:
  • Spodoptera frugiperda
  • Not provided