8dps

Electron Microscopy
3.47Å resolution

The structure of the interleukin 11 signalling complex, truncated gp130

Released:

Function and Biology Details

Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
PDBe Complex ID:
PDB-CPX-273343 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (5 distinct):
Interleukin-6 receptor subunit beta Chains: A, D
Molecule details ›
Chains: A, D
Length: 303 amino acids
Theoretical weight: 34.56 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P40189 (Residues: 22-324; Coverage: 34%)
Gene name: IL6ST
Sequence domains:
Interleukin-11 Chains: B, E
Molecule details ›
Chains: B, E
Length: 169 amino acids
Theoretical weight: 18.27 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P20809 (Residues: 32-199; Coverage: 94%)
  • Best match: P20809-2 (Residues: 1-120)
Gene name: IL11
Sequence domains: Interleukin 11
Soluble interleukin-11 receptor subunit alpha Chains: C, F

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer : NEW Components: NAG, BMA
1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.47Å
Relevant EMDB volumes: EMD-27641
Expression systems:
  • Spodoptera frugiperda
  • Escherichia coli