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Cryo-EM structure of Arabidopsis SPY in complex with GDP-fucose

Source organism: Arabidopsis thaliana
Biochemical function: protein O-acetylglucosaminyltransferase activity
Biological process: regulation of reactive oxygen species metabolic process
Cellular component: cytoplasm

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EC 2.4.1.255: Protein O-GlcNAc transferase

Reaction catalysed:
UDP-N-acetyl-alpha-D-glucosamine + [protein]-L-serine = UDP + [protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-serine
Systematic name:
UDP-N-acetyl-D-glucosamine:protein-O-beta-N-acetyl-D-glucosaminyl transferase
Alternative Name(s):
  • O-GlcNAc transferase
  • O-linked N-acetylglucosaminyltransferase
  • OGTase
  • Protein O-linked beta-N-acetylglucosamine transferase
  • Uridine diphospho-N-acetylglucosamine:polypeptide beta-N-acetylglucosaminyltransferase

EC 2.4.1.221: Peptide-O-fucosyltransferase

Reaction catalysed:
GDP-beta-L-fucose + [protein]-(L-serine/L-threonine) = GDP + [protein]-3-O-(alpha-L-fucosyl)-(L-serine/L-threonine)
Systematic name:
GDP-beta-L-fucose:[protein]-(L-serine/L-threonine) O-alpha-L-fucosyltransferase (configuration-inverting)
Alternative Name(s):
  • GDP-L-fucose:polypeptide fucosyltransferase
  • GDP-fucose protein O-fucosyltransferase
  • GDP-fucose:polypeptide fucosyltransferase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF00515
Domain description: Tetratricopeptide repeat
Occurring in:
  1. Probable UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase SPINDLY
The deposited structure of PDB entry 8dti contains 8 copies of Pfam domain PF00515 (Tetratricopeptide repeat) in Probable UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase SPINDLY. Showing 4 copies in chain A.

PF13844
Domain description: Glycosyl transferase family 41
Occurring in:
  1. Probable UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase SPINDLY
The deposited structure of PDB entry 8dti contains 4 copies of Pfam domain PF13844 (Glycosyl transferase family 41) in Probable UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase SPINDLY. Showing 2 copies in chain A.

InterPro InterPro annotations
IPR019734
Domain description: Tetratricopeptide repeat
Occurring in:
  1. Probable UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase SPINDLY
IPR011990
Domain description: Tetratricopeptide-like helical domain superfamily
Occurring in:
  1. Probable UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase SPINDLY
IPR006597
Domain description: Sel1-like repeat
Occurring in:
  1. Probable UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase SPINDLY
IPR029489
Domain description: O-GlcNAc transferase, C-terminal
Occurring in:
  1. Probable UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase SPINDLY

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